March Madness betting players are coming to the end of one of the craziest Tournaments in the history of the NCAA, as no No.1 seed reached the Final Four for the first time, and one matchup features the highest combination of seeds ever. Here are our Final Four picks for the weekend.

VCU Butler Betting – Saturday, 6:05 PM ET

The Bulldogs are 2.5-point favorites in their first meeting with the Rams, and with Butler as a No.8 seed and VCU as a No.11, this is the highest combination of seeds to meet in the Final Four. The Rams have been rolling through the Tournament to the surprise of, well, everyone, while Butler, who was a finalist last year, have gotten here by the skin of their teeth. VCU’s three-point shooting has been the difference in their run, but we think the Bulldogs are going to make it tough for them to get going from the outside, which is why we’re taking Butler.

UConn Kentucky Betting – Saturday, 8:45 PM ET

The Wildcats are 2.5-point favorites against the Huskies, who beat Kentucky in the 2006 Tournament, and then they romped over the Wildcats in the final of the Maui tournament earlier this year. We expect Kentucky to remember that beating and take it to the Huskies, especially Brandon Knight, who was dominated by UConn’s Kemba Walker. The Huskies are 12-0 in tournament games this season, but the run will be ended by an athletic Kentucky team anchored by a surprising big man in Josh Harrelson. Go with Kentucky in your online sports betting picks.

March Madness betting players are starting their research for the Big Dance ahead of the conference tournaments, and there are a lot of teams who have a legitimate chance of winning it all. But we’re taking the deepest team in the country, and only a lack of discipline will hurt them.

Try and name something that Kansas doesn’t have. Looking for depth? The Jayhawks have 10 players averaging at least 12 points, and the productivity doesn’t drop off much when the second unit comes in. The team is so deep that they didn’t even miss starting point guard Tyshawn Taylor, who was suspended for two games, because they have at least three players who could take his place. How about scoring? The Jayhawks are fourth in the country in points scored, first in field-goal percentage and they lead the country in assists. They’re 17th in the country from the three-point line, and in the Morris brothers, Markieff and Marcus, Kansas has two players who can score in the post.

The only things that can stop Kansas is discipline, as shown by the suspension of Taylor. As we said, the Jayhawks have depth, but indiscipline also ruins a team’s routine. Also, the Jayhawks are terrible at the foul line, coming in 215th in the country, and if you look at a quick way to end your NCAA Tournament run, missing your free throws is one of the top ways to do so. But coach Bill Self seems to have these guys ready and playing for one cause, and the Jayhawks are going to be a force at your online sportsbook in late March.

Super Bowl betting players are preparing for their version of the Final Four, but we all know the real Final Four comes from college hoops, and here are our picks to make it to Houston.

Ohio State

The Buckeyes have the best big man in the country in freshman Jared Sullinger, and he’s surrounded by experienced shooters in Jon Diebler and David Lighty, along with William Buford. The Buckeyes should also be able to snag a No.1 seed as the class of the Big Ten.

Kansas

The Jayhawks have experienced players like Markieff and Marcus Morris, along with Tyrel Reed and Brady Morningstar. The X-factor is freshman Josh Selby, who is probably the most talented player on the team, but he still makes some poor decisions. Still, Kansas is the deepest team in the nation and can overcome that.

Syracuse

It’s really tough to figure out who will come out of the Big East, and it’s between UConn and Syracuse. We’re giving the edge to the Orangemen because of their 2-3 zone that forces teams to shoot from the outside, which boosts their chances. Syracuse also has one of the top forward duos in the country in Kris Joseph and Rick Jackson.

Texas

The Longhorns are a much better team than last year, as in, they play much better as a team. They can score from the perimeter, but the emergence of Tristan Thompson in the post makes Texas a real threat, so don’t wait until March to jump on their sports betting odds.

After a seemingly very long February (how is that month only 28 days?!), it’s finally time to get March Madness betting in gear — it’s Selection Sunday in only a few days, and right now we’re at the epicenter of the Pac 10 tournament, which is a great preview of the NCAAB teams lucky – and talented – enough to go from here to the big tourney.

Pac 10 this weekend is tricky, especially when you’ve got March Madness odds to consider. Personally, I think the safest bet here is either UCLA or Washington. The Bruins have won in two of the last three years, and so it’s obvious that they’ll be a favorite at the offshore sportsbooks; Washington, conversely, are ready to defend their constant regular-season domination.

However, it’s hard to overlook the Arizona Wildcats who, although they’re on the bubble, have made it into March Madness the last 25 times running.

These kids are scrappy and don’t like backing down without a fight, so look for them to make some noise against Arizona State. Although they’ve lost the last two matchups with their state rival this season, there’s a lot more on the line right now — including a possible match with Washington, against whom Arizona is 1-1. If the Wildcats can pull it together, they’ll be serious contenders in the Pac 10 Tournament lines; if all else fails, though, stick with UCLA. March Madness is just around the corner…